13950-62-4

Basic information

• Product Name: ethyl 5-methyl-3-phenylisothiazole-4-carboxylate
• Synonyms: ethyl 5-methyl-3-phenylisothiazole-4-carboxylate
• CAS NO: 13950-62-4
• Molecular Weight: 247.318
• Mol File: 13950-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 5-methyl-3-phenylisothiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-methyl-3-phenylisothiazole-4-carboxylate(13950-62-4)
• EPA Substance Registry System: ethyl 5-methyl-3-phenylisothiazole-4-carboxylate(13950-62-4)

Safety Data

• Hazardous Substances Data: 13950-62-4(Hazardous Substances Data)

Upstream product

• 100-47-0 benzonitrile 
• 141-97-9 ethyl acetoacetate 
• 29682-53-9 5-methyl-1,2,3-thiadiazole-4-carboxylic acid ethyl ester 
• 21486-57-7 2-(amino-phenyl-methylene)-3-oxo-butyric acid ethyl ester 

Downstream Products

• 1172589-45-5 4-hydroxy-3-phenyl-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 
• 1172589-46-6 7-bromo-4-hydroxy-3-phenyl-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 
• 1172589-51-3 4-hydroxy-3-phenyl-7-pyridin-3-yl-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 
• 1172589-47-7 7-(4-fluoro-phenyl)-4-hydroxy-3-phenyl-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 
• 1172589-44-4 6-(2,4-dimethoxy-benzyl)-4-oxo-3-phenyl-4,5,6,7-tetrahydro-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 
• 1172589-42-2 {[7-(4-fluoro-phenyl)-4-hydroxy-3-phenyl-isothiazolo[5,4-c]pyridine-5-carbonyl]-amino}-acetic acid 
• 1172589-43-3 N-(2,4-dimethoxy-benzyl),N-(ethyl ethanylat-2-yl)-5-aminomethyl-3-phenyl-isothiazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of Isothiazole via the Rhodium-Catalyzed Transannulation of 1,2,3-Thiadiazoles with Nitriles

A synthetic method for obtaining a wide variety of isothiazoles by the Rh-catalyzed transannulation of 1,2,3-thiadiazoles with alkyl, aryl, and heteroaryl nitriles, which proceeds via an α-thiavinyl Rh-carbenoid intermediate, was developed. The results suggest that during its reaction with nitriles, the α-thiavinyl carbene acts as an umpolung 1,3-dipole equivalent, in contrast to its behavior during its reaction with alkynes. The developed method was successfully employed to synthesize pentaoligomeric arylene compounds consisting of three benzene and two isothiazole rings.

ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY

The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).