1395082-80-0

Basic information

• Product Name: 2-cyano-N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)acetamide
• Synonyms: 2-cyano-N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)acetamide
• CAS NO: 1395082-80-0
• Molecular Weight: 281.274
• Mol File: 1395082-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyano-N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)acetamide(1395082-80-0)
• EPA Substance Registry System: 2-cyano-N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)acetamide(1395082-80-0)

Safety Data

• Hazardous Substances Data: 1395082-80-0(Hazardous Substances Data)

Upstream product

• 372-09-8 cyanoacetic acid 
• 155579-43-4 5-amino-1-(4-methoxyphenyl)-1H-imidazole-4-carbonitrile 

Downstream Products

• 1395082-69-5 N-(4-cyano-1-(4-methoxyphenyl)-1H-imidazol-5-yl)-2-imino-8-methoxy-2H-chromene-3-carboxamide 

Relevant articles and documents

New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships

In silico screening of a collection of 1584 academic compounds identified a small molecule hit for the human adenosine A2A receptor (pK i = 6.2) containing a novel chromene scaffold (3a). To explore the structure-activity relationships of this new chemical series for adenosine receptors, a focused library of 43 2H-chromene-3-carboxamide derivatives was synthesized and tested in radioligand binding assays at human adenosine A 1, A2A, A2B and A3 receptors. The series was found to be enriched with bioactive compounds for adenosine receptors, with 14 molecules showing submicromolar affinity (pKi ≥ 6.0) for at least one adenosine receptor subtype. These results provide evidence that the chromene scaffold, a core structure present in natural products from a wide variety of plants, vegetables, and fruits, constitutes a valuable source for novel therapeutic agents.