1395097-37-6Relevant articles and documents
Total synthesis of (±)-hirsutine: Application of phosphine-catalyzed imine-allene [4 + 2] annulation
Villa, Reymundo A.,Xu, Qihai,Kwon, Ohyun
, p. 4634 - 4637 (2012/10/30)
The total synthesis of the indole alkaloid hirsutine has been achieved, with a key step being the application of our phosphine-catalyzed [4 + 2] annulation of an imine with ethyl α-methylallenoate. From commercially available indole-2-carboxaldehyde, the target was synthesized in 14 steps and 6.7% overall yield.