13957-27-2

Basic information

• Product Name: 1-(bromoethynyl)cyclohexanol
• Synonyms: cyclohexanol, 1-(2-bromoethynyl)-
• CAS NO: 13957-27-2
• Molecular Formula: C₈H₁₁BrO
• Molecular Weight: 203.0763
• Mol File: 13957-27-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 267.9°C at 760 mmHg
• Flash Point: 115.8°C
• Density: 1.48g/cm³
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 1-(bromoethynyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromoethynyl)cyclohexanol(13957-27-2)
• EPA Substance Registry System: 1-(bromoethynyl)cyclohexanol(13957-27-2)

Safety Data

• Hazardous Substances Data: 13957-27-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(bromoethynyl)cyclohexanol is used as a precursor in the pharmaceutical industry for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block in the development of new medications.
Used in Organic Chemical Reactions:
In the field of organic chemistry, 1-(bromoethynyl)cyclohexanol is utilized as an intermediate in a range of chemical reactions. Its reactivity and functional groups make it a useful component in creating complex organic molecules.
Used as a Reagent in Organic Chemistry:
1-(bromoethynyl)cyclohexanol is also employed as a reagent in organic chemistry, where it aids in various chemical processes and reactions, contributing to the synthesis of target compounds.
Used in the Production of Specialty Chemicals:
BCE serves as a building block in the manufacturing of specialty chemicals, which are often used in specific industries for their unique properties and applications.
Safety Measures:
Due to its toxic nature and potential to cause irritation, 1-(bromoethynyl)cyclohexanol requires careful handling with appropriate safety measures and protective equipment to ensure the safety of those who work with it.

Upstream product

• 78-27-3 1-Ethynylcyclohexan-1-ol 
• 593-61-3 bromoethyne 
• 108-94-1 cyclohexanone 

Downstream Products

• 32837-89-1 3-(1-hydroxycyclohexyl)prop-2-ynenitrile 
• 100849-70-5 2-hydroxy-1-(1-hydroxycyclohexyl)ethan-1-one 
• 5768-10-5 1,4-bis(1-hydroxycyclohexyl)buta-1,3-diyne 
• 1217554-50-1 1-(4-methoxyphenyl)-4-(1-cyclohexenyl)buta-1,3-diyne 
• 27971-34-2 6-(1-Hydroxycyclohexyl)-3,5-hexadiyn-1-ol 
• 1431380-93-6 1-(5-hydroxy-5-phenylhexa-1,3-diyn-1-yl)cyclohexanol 

Relevant articles and documents

Chemo-and regiospecific modification of D,L-tryptophan by reaction with α,β-acetylenic γ-hydroxy nitriles

D,L-Tryptophan reacts with α,β-acetylenic γ-hydroxy nitriles, chemo-and regiospecifically, under mild, green conditions via a hydroamination-type process involving the primary amine group. The hydroxycyanopropanyl substituent of the initial adducts underg

Alkene Difunctionalization Triggered by a Stabilized Allenyl Radical: Concomitant Installation of Two Unsaturated C?C Bonds

Radical-mediated difunctionalization of alkenes provides a promising approach to introduce one alkenyl or alkynyl group to target compounds. However, simultaneous installation of two unsaturated C?C bonds via alkene difunctionalization remains elusive, at

Microwave-Assisted Organocatalyzed Rearrangement of Propargyl Vinyl Ethers to Salicylaldehyde Derivatives: An Experimental and Theoretical Study

The microwave-assisted imidazole-catalyzed transformation of propargyl vinyl ethers (PVEs) into multisubstituted salicylaldehydes is described. The reaction is instrumentally simple, scalable, and tolerates a diverse degree of substitution at the propargylic position of the starting PVE. The generated salicylaldehyde motifs incorporate a broad range of topologies, spanning from simple aromatic monocycles to complex fused polycyclic systems. The reaction is highly regioselective and takes place under symmetry-breaking conditions. The preparative power of this reaction was demonstrated in the first total synthesis of morintrifolin B, a benzophenone metabolite isolated from the small tree Morinda citrifolia L. A DFT study of the reaction was performed with full agreement between calculated values and experimental results. The theoretically calculated values support a domino mechanism comprising a propargyl Claisen rearrangement, a [1,3]-H shift, a [1,7]-H shift (enolization), a 6π electrocyclization, and an aromatization reaction.