13957-54-5

Basic information

• Product Name: 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003295;1-[4-(TRIFLUOROMETHOXY)PHENYL]HYDRAZINE HYDROCHLORIDE;BUTTPARK 44\57-15;[4-(trifluoromethoxy)phenyl]hydrazine(SALTDATA: HCl);1-[4-(trifluoromethoxy)phenyl]hydrazine
• CAS NO: 13957-54-5
• Molecular Formula: C₇H₇F₃N₂O
• Molecular Weight: 228.6
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 13957-54-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 230 °C(lit.)
• Boiling Point: 228.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.408±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.91±0.20(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE(13957-54-5)
• EPA Substance Registry System: 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE(13957-54-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13957-54-5(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethoxy)phenylhydrazine hydrochloride, also known as 4-Phenyltrifluoromethoxyphenylhydrazine hydrochloride, is a chemical compound with the molecular formula C8H8F3N2O·HCl. It is a white solid with a molecular weight of 232.62 g/mol. 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE is used in organic synthesis as a reagent for the preparation of phenylhydrazones, which are important intermediates in the synthesis of various organic compounds. It has also been studied for its potential use as a selective inhibitor of phosphodiesterase 4, which is an enzyme involved in various physiological and pathological processes. 4-(Trifluoromethoxy)phenylhydrazine hydrochloride is a potentially useful compound with a range of applications in chemistry and pharmacology.

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 461-81-4 1-chloro-4-(trifluoromethoxy)benzene 
• 1351557-28-2 di-tert-butyl 1-(4-(trifluoromethoxy)phenyl)hydrazine-1,2-dicarboxylate 

Downstream Products

• 1496328-62-1 1-phenyl-2-(4-(trifluoromethoxy)phenyl)ethan-1-one 

Relevant articles and documents

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure relates to novel boron-containing compounds and their novel uses, e.g., as active ingredients that have pesticidal activity. The disclosure also relates to agrochemical compositions and their use in agriculture or horticulture for the control or prevention of infestation of plants, plant parts, plant propagation materials, harvested food crops, or seeds by pests, specifically fungi and nematodes. The disclosure further relates to methods for promoting plant performance and/or curatively or preventively controlling phytopathogens, (particularly fungi and nematodes) on or in a plant, plant parts, plant propagation materials, seeds, harvested fruits, or vegetables.

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

NOVEL OXADIAZINONE DERIVATIVES AND USE THEREOF AS PPAR-ALPHA MODULATORS

The invention relates to novel 1,3,4-oxadiazine-5-on derivatives of general formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for the treatment and/