139617-95-1

Basic information

• Product Name: Thiophene, 2-[(2,5-dimethoxyphenyl)methyl]-2,5-dihydro-3-methyl-, 1,1-dioxide
• CAS NO: 139617-95-1
• Molecular Formula: C14H18O4S
• Molecular Weight: 282.361
• Mol File: 139617-95-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-[(2,5-dimethoxyphenyl)methyl]-2,5-dihydro-3-methyl-, 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-[(2,5-dimethoxyphenyl)methyl]-2,5-dihydro-3-methyl-, 1,1-dioxide(139617-95-1)
• EPA Substance Registry System: Thiophene, 2-[(2,5-dimethoxyphenyl)methyl]-2,5-dihydro-3-methyl-, 1,1-dioxide(139617-95-1)

Safety Data

• Hazardous Substances Data: 139617-95-1(Hazardous Substances Data)

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 1193-10-8 3-methyl-2,5-dihydrothiophen-1,1-dioxide 
• 60732-17-4 2,5-dimethoxybenzyl bromide 

Downstream Products

• 851182-72-4 2-((2,5-dimethoxyphenyl)methyl)-3-methylcyclohex-3-enecarbaldehyde 
• 851182-74-6 2-((2,5-dimethoxyphenyl)methyl)-1,3-dimethylcyclohex-3-enecarbaldehyde 
• 139618-05-6 (E)-3-methyl-(2',5'-dimethoxyphenyl)-1,3-pentadiene 

Relevant articles and documents

Design, synthesis and biological evaluation of novel riccardiphenol analogs

A novel, facile, high yield, and less cumbersome synthesis of riccardiphenol analogs is described. The synthesized compounds were characterized and assessed for its in vitro activity in a panel of human cancer cell lines of differing origin: HuCCT-1, BxPC3, Panc-1, Mia-Paca, A431, Hep2, and HN006. HuCCT-1 was derived from an intrahepatic cholangiocarcinoma; BxPC3, Mia-Paca, and Panc-1 were derived from pancreatic cancers; A431 was derived from a vulvar epithelial carcinoma; and Hep2 and HN006 were derived from squamous cell carcinomas of the head and neck. The cytotoxicity of a newly developed riccardiphenol analog against human cancer cell lines was assessed. The cancer cells exhibited varying sensitivities to the compound, with IC50 values from 30 to 50 μM. This susceptibility was particularly interesting in the case of lines such as Hep2 and BxPC3 that are resistant to classic cytotoxic drugs as well as some targeted agents. These results demonstrate that the novel riccardiphenol analog has effective action against human-derived cancer cell in vitro.