139713-80-7 Usage
Description
16-Hydroxytriptolide is a diterpenoid triepoxide naturally isolated from the Tripterygium wilfordii plant. It is known for its potent anti-inflammatory properties, as well as its strong immunosuppressive and antifertility activities, making it a promising candidate for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
16-Hydroxytriptolide is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. Its strong immunosuppressive properties also make it a potential candidate for treating autoimmune diseases and conditions where the immune system is overactive.
Used in Fertility Regulation:
Due to its antifertility activities, 16-Hydroxytriptolide can be used as a contraceptive agent, helping to regulate fertility and prevent unwanted pregnancies.
Used in Immunosuppressive Therapy:
In the field of organ transplantation and treatment of autoimmune diseases, 16-Hydroxytriptolide is used as an immunosuppressive agent to prevent organ rejection and manage the immune response. Its potent immunosuppressive properties can help maintain the health of transplanted organs and reduce the severity of autoimmune conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 139713-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,7,1 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 139713-80:
(8*1)+(7*3)+(6*9)+(5*7)+(4*1)+(3*3)+(2*8)+(1*0)=147
147 % 10 = 7
So 139713-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O7/c1-8(6-21)18-13(26-18)14-20(27-14)17(2)4-3-9-10(7-24-15(9)22)11(17)5-12-19(20,25-12)16(18)23/h8,11-14,16,21,23H,3-7H2,1-2H3/t8-,11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
139713-80-7Relevant articles and documents
Divergent total synthesis of triptolide, triptonide, tripdiolide, 16-hydroxytriptolide, and their analogues
Xu, Hongtao,Tang, Huanyu,Feng, Huijin,Li, Yuanchao
, p. 10110 - 10122 (2015/02/19)
A divergent route was developed for the formal total synthesis of triptolide, triptonide, and tripdiolide, as well as a total synthesis of 16-hydroxytriptolide and their analogues in an enantioselective form. Common advanced intermediate 5 was concisely assembled by employing an indium(III)-catalyzed cationic polycyclization reaction and a palladium-catalyzed carbonylation-lactone formation reaction as key steps. This advanced intermediate was readily converted to the above natural products by using palladium-catalyzed cross-coupling or the Claisen rearrangement reaction as key steps. Additionally, preliminary structure-cytotoxic activity relationship studies of C13 suggested that it might be a new modification site that could still retain the cytotoxicity.
