13972-97-9 Usage
Description
3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester is an organic compound derived from isoquinoline, a heterocyclic compound with a benzene ring fused to a pyridine ring. It is characterized by the presence of a carboxylic acid group, a hydroxyl group, and a methyl ester group. 3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester exhibits unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester is used as a precursor for the synthesis of FG 2216 (F329000), an erythropoietic agent. FG 2216 is an orally active prolyl-hydroxylase inhibitor that increases erythropoietin production in end-stage kidney disease, making it a valuable compound for the treatment of anemia associated with chronic kidney disease.
Used in Chemical Synthesis:
3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester can also be utilized as an intermediate in the synthesis of various other organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its unique structure and functional groups make it a versatile building block for the development of new molecules with specific properties and functions.
Used in Research and Development:
3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester can be employed in research and development efforts to explore its potential as a bioactive molecule. Its chemical properties and structural features may provide insights into the design and development of new drugs, materials, or other applications that can benefit from its unique characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 13972-97-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,7 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13972-97:
(7*1)+(6*3)+(5*9)+(4*7)+(3*2)+(2*9)+(1*7)=129
129 % 10 = 9
So 13972-97-9 is a valid CAS Registry Number.
13972-97-9Relevant articles and documents
Convergent synthesis of 1,1′-biisoquinolines tethered to calamitic subunits
Kapatsina, Elisabeth,Lordon, Marie,Baro, Angelika,Laschat, Sabine
body text, p. 2551 - 2560 (2009/04/07)
A convergent synthesis of a series of 4,4′-functionalized 1,1′-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepared by Williamson etherification of the respective 4-hydroxybiphenyl and -phenylpyrimidine precursors with dibromoalkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine ethyl ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of potassium carbonate gave the isoquinolines, which were submitted to a nickel(II) chloride mediated homocoupling to yield the ligand systems. Georg Thieme Verlag Stuttgart.
