1397264-86-6

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2E)-6,6-difluoro-7-[(4-methoxyphenyl)amino]-7-oxohept-2-enoate
• Synonyms: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2E)-6,6-difluoro-7-[(4-methoxyphenyl)amino]-7-oxohept-2-enoate
• CAS NO: 1397264-86-6
• Molecular Weight: 513.625
• Mol File: 1397264-86-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2E)-6,6-difluoro-7-[(4-methoxyphenyl)amino]-7-oxohept-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2E)-6,6-difluoro-7-[(4-methoxyphenyl)amino]-7-oxohept-2-enoate(1397264-86-6)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2E)-6,6-difluoro-7-[(4-methoxyphenyl)amino]-7-oxohept-2-enoate(1397264-86-6)

Safety Data

• Hazardous Substances Data: 1397264-86-6(Hazardous Substances Data)

Upstream product

• 1397264-51-5 2,2-difluoro-N-(4-methoxyphenyl)hex-5-enamide 
• 72526-00-2 (-)-8-phenylmenthyl acrylate 

Downstream Products

• 1397264-74-2 (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl [5,5-difluoro-1-(4-methoxyphenyl)-6-oxopiperidin-2-yl]acetate 
• 1397264-73-1 (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl [5,5-difluoro-1-(4-methoxyphenyl)-6-oxopiperidin-2-yl]acetate 

Relevant articles and documents

A new tandem cross metathesis-intramolecular aza-Michael reaction for the synthesis of α,α-difluorinated lactams

A new tandem cross metathesis-intramolecular aza-Michael reaction in which an α,α-difluorinated amide serves as a source of nucleophilic nitrogen is described. This process gives rise to a new family of fluorinated γ- and δ-lactams. The tandem protocol is catalyzed by the Hoveyda-Grubbs second-generation ruthenium catalyst with titanium(IV) tetraisopropoxide as a co-catalyst and it is highly efficient when conjugated ketones are used as the Michael acceptors. With conjugated esters, however, it is necessary to perform a step-by-step procedure in which the cyclization event is activated by the addition of a base. An asymmetric version of the process is also evaluated. Georg Thieme Verlag Stuttgart · New York.