139755-82-1 Usage
Description
DESMETHYL SILDENAFIL, also known as S435001, is a metabolite of Sildenafil, an orally active selective type 5 cGMP phosphodiesterase inhibitor. It is a white solid with chemical properties that contribute to its various applications.
Uses
Used in Pharmaceutical Industry:
DESMETHYL SILDENAFIL is used as a therapeutic agent for treating erectile dysfunction. As a metabolite of Sildenafil, it functions as a selective type 5 cGMP phosphodiesterase inhibitor, enhancing blood flow to the penis and facilitating an erection in response to sexual stimulation.
Additionally, DESMETHYL SILDENAFIL may be used as a research compound for studying the effects of phosphodiesterase inhibition on various physiological processes, potentially leading to the development of new treatments for other conditions related to cGMP regulation.
Used in Research and Development:
DESMETHYL SILDENAFIL serves as a valuable compound in the field of research and development, particularly in the study of cGMP signaling pathways and their role in various physiological and pathological processes. Its use in research can contribute to the advancement of medical knowledge and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 139755-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,7,5 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 139755-82:
(8*1)+(7*3)+(6*9)+(5*7)+(4*5)+(3*5)+(2*8)+(1*2)=171
171 % 10 = 1
So 139755-82-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H28N6O4S/c1-4-6-16-18-19(26(3)25-16)21(28)24-20(23-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-22-10-12-27/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,23,24,28)
139755-82-1Relevant articles and documents
Structure elucidation of phototransformation products of unapproved analogs of the erectile dysfunction drug sildenafil in artificial freshwater with UPLC-Q Exactive-MS
Acea, Jaume,Prez, Sandra,Gardinali, Piero,Abad, Jos Luis,Eichhorn, Peter,Heuett, Nubia,Barcel, Dami
, p. 1279 - 1289 (2014)
In this study, four unapproved analogues of Sildenafil (SDF) were photodegraded under synthetic sunlight in artificial freshwater. Homosildenafil (H-SDF), hydroxyhomo-sildenafil (HH-SDF), norneosildenafil (NR-SDF) and thiosildenafil (T-SDF) were selected because they are frequently detected as adulterants in natural herbal products. Using UPLC-Orbitrap (QExactive)-MS, six photoproducts common to H-SDF, HH-SDF and T-SDF and nine unique transformation products of different molecular weights were identified based on their high-resolution (+)ESI product ion spectra. Mass spectral analysis of deuterated H-SDF, labeled on the N-ethyl group, allowed to gain mechanistic insight into the fragmentation pathway of the substituted piperazine ring and to support the postulated photoproduct structures. The mass spectral fragmentation confirmed the stepwise destruction of the piperazine ring eventually producing a sulfonic acid derivative (C17H20N4O5S: 392.1151Da). In contrast, the photodegradation of NR-SDF, which lacks a piperazine ring in its structure, formed only two prominent photoproducts originating from N,Ndealkylation of the sulfonamide followed by hydrolysis. The current work constitutes the first study on the photodegradation of analogs of erectile dysfunction drugs and the first detection of two transformation products (m/z 449 and 489) in environmental samples.
