1397691-96-1Relevant articles and documents
Concise Synthesis of v-Coelenterazines
Hosoya, Takamitsu,Iimori, Rie,Yoshida, Suguru,Sumida, Yuto,Sahara-Miura, Yuiko,Sato, Jun-Ichi,Inouye, Satoshi
, p. 3888 - 3891 (2015)
A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-cou
PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS
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Page/Page column 19, (2012/09/22)
A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).