1398506-77-8

Basic information

• Product Name: C₂₅H₂₄N₂O₇
• Synonyms: C₂₅H₂₄N₂O₇
• CAS NO: 1398506-77-8
• Molecular Weight: 464.475
• Mol File: 1398506-77-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₄N₂O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₄N₂O₇(1398506-77-8)
• EPA Substance Registry System: C₂₅H₂₄N₂O₇(1398506-77-8)

Safety Data

• Hazardous Substances Data: 1398506-77-8(Hazardous Substances Data)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 125-29-1 Hydrocodone 

Relevant articles and documents

POLYSUBUNIT OPIOID PRODRUGS RESISTANT TO OVERDOSE AND ABUSE

The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct by a specified gastrointestinal enzyme directly, or indirectly, releases an opioid when taken orally as prescribed. The gastrointestinal enzyme mediated release of opioid from constructs of the invention is designed to be attenuated in vivo via a saturation or inhibition mechanism when overdoses are ingested. The invention further provides constructs that are highly resistant to oral overdose, chemical tampering, and abuse via non-oral routes of administration.

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.