139886-27-4 Usage
Description
(E)-N-hydroxy-1-(1,2,5,6-tetrahydropyridin-3-yl)methanimine hydrochloride (1:1) is a complex organic chemical compound characterized by the presence of a hydroxy group, a tetrahydropyridin-3-yl moiety, and a methanimine group, all connected to a hydrochloride salt. Also referred to as (E)-2-(hydroxymethyl)-N-(5,6,7,8-tetrahydropyridin-3-yl)ethanimine hydrochloride, this compound holds promise in the fields of organic synthesis and medicinal chemistry.
Uses
Used in Organic Synthesis:
(E)-N-hydroxy-1-(1,2,5,6-tetrahydropyridin-3-yl)methanimine hydrochloride (1:1) is used as a key building block in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-N-hydroxy-1-(1,2,5,6-tetrahydropyridin-3-yl)methanimine hydrochloride (1:1) is utilized for its potential to contribute to the development of new drugs. Its structural components may offer novel interactions with biological targets, possibly leading to the discovery of innovative treatments for various diseases.
Used in Research and Development:
Due to its chemical complexity and potential biological activities, (E)-N-hydroxy-1-(1,2,5,6-tetrahydropyridin-3-yl)methanimine hydrochloride (1:1) is a target for research in both academia and the pharmaceutical industry. Its study may reveal new insights into chemical reactivity and biological mechanisms, ultimately contributing to the advancement of drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 139886-27-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,8,8 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 139886-27:
(8*1)+(7*3)+(6*9)+(5*8)+(4*8)+(3*6)+(2*2)+(1*7)=184
184 % 10 = 4
So 139886-27-4 is a valid CAS Registry Number.
139886-27-4Relevant articles and documents
1-Alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-alkyl-oximes: A new class of potent orally active muscarinic agonists related to arecoline
Toja,Bonetti,Butti,Hunt,Fortin,Barzaghi,Formento,Maggioni,Nencioni,Galliani
, p. 853 - 868 (2007/10/02)
On the basis of the knowledge acquired for basic studies of several known arecoline derivatives about the structural requirements for potent agonistic activity and oral efficacy, a series of 1-alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-alkyl-oximes was synthesized and biologically evaluated in a battery of in vitro and in vivo assays. The most interesting molecules to emerge from the primary screening, 1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride (11, RU 35963), 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxyaldehyde-O-methyloxime hydrochloride (12, RU 35926), and 1,2,5,6-tetrahydropyridine-3-carboxyaldehyde-O-propargyloxime hydrochloride (30, RU 47029) and 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-propargyloxime hydrochloride (33, RU 35986), were evaluated more extensively, and their cholinomimetic profile was compared with that of the parent molecule, arecoline. The pharmacological results after oral administration to mice and rats revealed that their efficacy is 2-3 orders of magnitude higher than that of arecoline, and, in addition, they show a longer duration of action. The 4 aldoximes showed anti-amnesic properties in many respects superior to those of arecoline. Their anti-amnesic doses were 2 orders of magnitude lower than those inducing obvious cholinergic symptoms, and 3-5 orders of magnitude lower than the lethal doses. These new compounds can be regarded as potential candidates for clinical studies in AD (Alzheimer's disease) patients.
