139924-17-7Relevant articles and documents
DNA CLEAVAGE REACTION OF ANTITUMOUR ANTIBIOTIC, KAPURIMYCIN A3, WITH DEOXYTETRANUCLEOTIDE D(CGCG)2
Chan, Kit Lam,Sugiyama, Hiroshi,Saito, Isao
, p. 7719 - 7722 (1991)
Kapurimycin A3 (kap A3, 1) , an antitumour antibiotic, alkylates N7 of guanine2 (G2) and G4 of d(C1G2C3G4)2 to produce their covalent adducts 2 (64percent) and 3 (7.0percent), respectively.Heating at 90 deg C for 5 min degraded both adducts to kap-3 - G adduct (5) with the concurrent release of their respective abasic-site containing oligomers 4 and 6.