1400435-37-1

Basic information

• Product Name: C₃₅H₅₉N₅O₈
• CAS NO: 1400435-37-1
• Molecular Weight: 677.882
• Mol File: 1400435-37-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₅₉N₅O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₅₉N₅O₈(1400435-37-1)
• EPA Substance Registry System: C₃₅H₅₉N₅O₈(1400435-37-1)

Safety Data

• Hazardous Substances Data: 1400435-37-1(Hazardous Substances Data)

Upstream product

• 1400435-83-7 C₂₀H₃₀N₂O₆ 
• 1400436-73-8 C₁₅H₂₂N₂O₄*C₂HF₃O₂ 
• 1422070-46-9 C₂₉H₄₇N₃O₈ 
• 1400437-20-8 C₂₄H₃₉N₃O₆ 
• 1400437-24-2 C₃₄H₅₆N₄O₉ 
• 1400437-29-7 C₂₉H₄₈N₄O₇ 
• 866528-89-4 N-Boc-N-methylisoleucinal 
• 17901-01-8 N-(tert-butoxycarbonyl)isoleucine methyl ester 
• 870640-59-8 (1S,2S)-(1-hydroxymethyl-2-methyl-butyl)-methyl-carbamic acid tert-butyl ester 
• 1400435-89-3 C₁₄H₂₇NO₅ 
• 1422070-40-3 C₁₃H₂₃NO₇ 
• 1422070-39-0 methyl N-Boc-6-amino-2,5-anhydro-3,4-di-O-methyl-6-deoxy-D-mannonate 
• 1400436-19-2 C₁₆H₃₁NO₅ 

Relevant articles and documents

A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death

We have synthesized eight analogues (D1-D8) of dolastatin 10 containing several unique amino acid subunits. Of these agents, D5 was found to be most effective in inhibiting both HeLa cell proliferation and microtubule assembly in vitro. At low nanomolar concentrations, D5 inhibited the proliferation of several types of cancer cells in culture. D5 bound to tubulin with a dissociation constant of 29.4 ± 6 μM. D5 depolymerized microtubules in cultured cells and produced mulitpolar spindles. At its half-maximal inhibitory concentration (15 nM), D5 strongly suppressed the dynamics of individual microtubules in live MCF-7 cells. D5 increased the accumulation of checkpoint proteins BubR1 and Mad2 at the kinetochoric region and caused G2/M block in these cells. The blocked cells underwent apoptosis with the activation of Jun N-terminal kinase. The results suggested that D5 exerts its antiproliferative action by dampening microtubule dynamics.