1400648-21-6

Basic information

• Product Name: 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
• Synonyms: 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
• CAS NO: 1400648-21-6
• Molecular Weight: 606.802
• Mol File: 1400648-21-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide(1400648-21-6)
• EPA Substance Registry System: 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide(1400648-21-6)

Safety Data

• Hazardous Substances Data: 1400648-21-6(Hazardous Substances Data)

Upstream product

• 394-41-2 3-fluoro-4-nitrophenol 
• 1647-26-3 1-bromo-2-cyclohexylethane 
• 181514-35-2 1-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one 
• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 
• 1400653-28-2 N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-N-(2,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 
• 1400653-03-3 7-bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonyl chloride 
• 32857-63-9 4-t-butylphenylacetic acid 
• 3549-23-3 methyl 2-(4-tert-butylphenyl)acetate 
• 1400648-22-7 2-[(4-tert-butylphenyl)acetyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-N-(2,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 

Downstream Products

• 1400648-23-8 2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(2-cyclohexylethoxy)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 

Relevant articles and documents

Identification of 2-[2-(4-tert-Butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)- 2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide as an Orally Active MGAT2 Inhibitor

We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline- 6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose of 100 mg/kg in a mouse oral lipid tolerance test. Further optimization of compound 2 to improve the intrinsic potency culminated in the identification of compound 11. Compound 11 showed a >50-fold lower IC50 against human MGAT2 enzyme than 2. Oral administration of 11 at a dose of 3 mg/kg in the oral lipid tolerance test resulted in significant suppression of triglyceride synthesis.