1401063-69-1Relevant articles and documents
A convenient method for the synthesis of aminomethylmonoalkylphosphinate
Ding, Derong,Yan, Guang
, p. 1906 - 1908 (2012/10/29)
Starting from the readily available 4-methylbenzoic acid, an efficient protocol for the preparation of ethyl 4-(aminomethyl) benzyl (methyl) phosphinate (1), a novel aminomethylmonoalkylphosphinate was reported in this communication. The important step involves the selective monochlorination of phosphonic ester by POCl3 and forming the phosphonochloridate, and followed by nucleophilic addition of CH3MgBr to the acid chloride intermediate.
