1401067-69-3

Basic information

• Product Name: (4R)-N-(3-((4-(2-aminophenyl)-4-((tert-butyldimethylsilyl)oxy)-butyl)amino)-3-oxopropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide
• Synonyms: (4R)-N-(3-((4-(2-aminophenyl)-4-((tert-butyldimethylsilyl)oxy)-butyl)amino)-3-oxopropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide
• CAS NO: 1401067-69-3
• Molecular Weight: 535.8
• Mol File: 1401067-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R)-N-(3-((4-(2-aminophenyl)-4-((tert-butyldimethylsilyl)oxy)-butyl)amino)-3-oxopropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-N-(3-((4-(2-aminophenyl)-4-((tert-butyldimethylsilyl)oxy)-butyl)amino)-3-oxopropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide(1401067-69-3)
• EPA Substance Registry System: (4R)-N-(3-((4-(2-aminophenyl)-4-((tert-butyldimethylsilyl)oxy)-butyl)amino)-3-oxopropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide(1401067-69-3)

Safety Data

• Hazardous Substances Data: 1401067-69-3(Hazardous Substances Data)

Upstream product

• 1401067-72-8 2-(4-((tert-butyldimethylsilyl)oxy)-4-(2-nitrophenyl)butyl)-isoindoline-1,3-dione 
• 1401067-58-0 2-(4-hydroxy-4-(2-nitrophenyl)butyl)isoindoline-1,3-dione 
• 137-08-6 calcium (R)-pantothenate 
• 1401067-68-2 (4R)-N-(3-((4-((tert-butyldimethylsilyl)oxy)-4-(2-nitrophenyl)butyl)amine)-3-oxo-propyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide 
• 167308-62-5 3-{[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]carbonylamino}propionic acid 
• 1401067-59-1 4-((tert-butyldimethylsilyl)oxy)-(2-nitrophenyl)butan-2-amine 

Downstream Products

• 1401067-57-9 (2R)-N-(3-((4-(2-aminophenyl)-4-hydroxybutyl)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide 

Relevant articles and documents

Validation of PqsD as an anti-biofilm target in pseudomonas aeruginosa by development of small-molecule inhibitors

2-Heptyl-4-hydroxyquinoline (HHQ) and Pseudomonas quinolone signal (PQS) are involved in the regulation of virulence factor production and biofilm formation in Pseudomonas aeruginosa. PqsD is a key enzyme in the biosynthesis of these signal molecules. Using a ligand-based approach, we have identified the first class of PqsD inhibitors. Simplification and rigidization led to fragments with high ligand efficiencies. These small molecules repress HHQ and PQS production and biofilm formation in P. aeruginosa. This validates PqsD as a target for the development of anti-infectives.