1401461-83-3

Basic information

• Product Name: (5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-(3,4-dimethoxyphenyl)amine
• Synonyms: (5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-(3,4-dimethoxyphenyl)amine
• CAS NO: 1401461-83-3
• Molecular Weight: 322.775
• Mol File: 1401461-83-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-(3,4-dimethoxyphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-(3,4-dimethoxyphenyl)amine(1401461-83-3)
• EPA Substance Registry System: (5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-(3,4-dimethoxyphenyl)amine(1401461-83-3)

Safety Data

• Hazardous Substances Data: 1401461-83-3(Hazardous Substances Data)

Upstream product

• 13479-88-4 5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine 
• 6315-89-5 3,4-dimethoxyaniline 

Downstream Products

• 1401462-40-5 methyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidine-3-carboxylate 
• 1401461-81-1 {3-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-phenyl}-methanol 
• 1401461-84-4 3-[7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl]benzoic acid methyl ester 
• 1401461-93-5 methyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidine-3-carboxylate 
• 1401461-05-9 3-[7-(3,4-dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-benzoic acid 
• 1401461-08-2 4-{3-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-benzoylamino}-benzoic acid 
• 1401461-31-1 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)-N-(2-(2-oxo-1,2-dihydropyridin-4-yl)ethyl)piperidine-4-carboxamide 
• 1401461-34-4 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)-N-(2-(pyridin-4-yl)ethyl)piperidine-3-carboxamide 
• 1401461-61-7 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)-N-(pyrazin-2-yl)piperidine-3-carboxamide 
• 1401461-85-5 4-{3-[7-(3,4-dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-benzoyl}-[1,4]-diazepane-1-carboxylic acid tert-butyl ester 
• 1401461-86-6 tert-butyl 4-(3-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzamido)benzoate 
• 1401461-94-6 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidine-3-carboxylic acid 
• 1401461-95-7 tert-butyl 4-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidine-3-carboxamido)benzoate 
• 1401462-02-9 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidine-4-carboxylic acid 

Relevant articles and documents

Rational design of highly selective spleen tyrosine kinase inhibitors

A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed phase II clinical trials, also exhibits some undesirable side effects. More selective Syk inhibitors could offer safer, alternative treatments. Through a systematic evaluation of the kinome, we identified Pro455 and Asn457 in the Syk ATP binding site as a rare combination among sequence aligned kinases and hypothesized that optimizing the interaction between them and a Syk inhibitor molecule would impart high selectivity for Syk over other kinases. We report the structure-guided identification of three series of selective spleen tyrosine kinase inhibitors that support our hypothesis and offer useful guidance to other researchers in the field.

THIAZOLOPYRIMIDINE COMPOUNDS

The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.