140171-66-0

Basic information

• Product Name: Amlodipine Dimethyl Ester
• Synonyms: Amlodipine Dimethyl Ester;AMlodipine IMpurity F (DiMethyl IMpurity);2-[(2-AMinoethoxy)Methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3,5-diMethyl Ester;3-Methyl 5-Methyl 4-(2-Chlorophenyl)-6-Methyl-2-[[2- [(2-aMinoethoxy)Methyl]-1,4-dihydropyridine-3,5-dicarboxylat;diMethyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate;AMlodipine IMpurity F(EP);AMlodipine EP IMpurity F;2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
• CAS NO: 140171-66-0
• Molecular Formula: C₁₉H₂₃ClN₂O₅
• Molecular Weight: 595.1041
• Product Categories: Aromatics;Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 140171-66-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 516.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.247±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 8.97±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Amlodipine Dimethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Amlodipine Dimethyl Ester(140171-66-0)
• EPA Substance Registry System: Amlodipine Dimethyl Ester(140171-66-0)

Safety Data

• Hazardous Substances Data: 140171-66-0(Hazardous Substances Data)

Usage

Uses

Amlodipine Besilate (A633500) impurity.

Upstream product

• 156366-27-7 N-tritylamlodipine 
• 98-11-3 benzenesulfonic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 111429-90-4 methyl 4-[2-(phthalimido)-ethoxy]acetoacetate 
• 21731-17-9 methyl 3-aminocrotonate 
• 89-98-5 2-chloro-benzaldehyde 
• 140171-50-2 phthaloyl amlodipine 

Relevant articles and documents

DIHYDROPYRIDINE COMPOUNDS HAVING SIMULTANEOUS ABILITY TO BLOCK L-TYPE CALCIUM CHANNELS AND TO INHIBIT PHOSPHODIESTERASE TYPE 3 ACTIVITY

The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.

Long-acting dihydropyridine calcium antagonists. 9. Structure activity relationships around amlodipine

The preparation of a range of 1,4-dihydropyridine analogues of amlodipine has been undertaken and their calcium antagonist activities on rat aorta have been evaluated.Increasing the size of the C5 ester group dramatically reduces calcium antagonist activity, a trend which would be compatible with the carbonyl group of that ester binding to the DHP receptor.Amlodipine analogues with extended C3 ester substituents also have lower potency than amlodipine, possibly because of disruption of a favourable interaction between the protonated amino group on the 2-substituentand the DHP receptor.Replacement of the 6-methyl substituent in amlodipine by alkoxyalkyl groups or electron-withdrawing groups is also detrimental to calcium antagonist activity. amlodipine / 1,4-dihydropyridine / structure activity relationship