1402431-71-3

Basic information

• Product Name: N-(1-nitro-4-oxo-3-phenoxybutan-2-yl)acetamide
• CAS NO: 1402431-71-3
• Molecular Weight: 266.254
• Mol File: 1402431-71-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-nitro-4-oxo-3-phenoxybutan-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-nitro-4-oxo-3-phenoxybutan-2-yl)acetamide(1402431-71-3)
• EPA Substance Registry System: N-(1-nitro-4-oxo-3-phenoxybutan-2-yl)acetamide(1402431-71-3)

Safety Data

• Hazardous Substances Data: 1402431-71-3(Hazardous Substances Data)

Upstream product

• 1238305-24-2 N-[(1Z)-2-nitroethenyl]acetamide 
• 2120-70-9 2-phenoxyethanal 

Relevant articles and documents

Thiol-free synthesis of oseltamivir and its analogues via organocatalytic michael additions of oxyacetaldehydes to 2-acylaminonitroalkenes

The organocatalytic addition of substituted oxyacetaldehydes to 2-acylaminonitroethenes proceeded with good to high diastereoselectivities and enantioselectivities. The resulting adducts reacted with ethyl 2-(diethoxyphosphoryl) acrylate to afford highly functionalized cyclohexenes. A thiol-free protocol for cyclization has been developed that leads to a separable mixture of two diastereoisomers. The unwanted diastereoisomer can be efficiently epimerized. The resulting cyclohexenes are precursors to oseltamivir and its analogues. The synthesis of the key reagent, 3-pentyloxyaldehyde, was also improved. Georg Thieme Verlag Stuttgart · New York.