1402602-05-4

Basic information

• Product Name: ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate
• Synonyms: ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate
• CAS NO: 1402602-05-4
• Molecular Weight: 290.334
• Mol File: 1402602-05-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate(1402602-05-4)
• EPA Substance Registry System: ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate(1402602-05-4)

Safety Data

• Hazardous Substances Data: 1402602-05-4(Hazardous Substances Data)

Upstream product

• 581778-88-3 (E)-ethyl 3-(4-bromo-2-fluorophenyl)acrylate 
• 6153-05-5 (Z)-3-methylpent-2-en-4-ynol 
• 1057674-14-2 ethyl 3-(4-bromo-2-fluorophenyl)propanoate 
• 3230-69-1 3-methyl-1-penten-4-yn-3-ol 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 1402601-88-0 (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoic acid 

Relevant articles and documents

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy

The free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for treatment of type 2 diabetes. However, to obtain optimal ligands, it may be necessary to limit both lipophilicity and polar surface area, translating to a need for small compounds. We here describe the identification of 24, a potent FFA1 agonist with low lipophilicity and very high ligand efficiency that exhibit robust glucose lowering effect.