1402918-49-3Relevant articles and documents
Chichibabin-type direct alkylation of pyridyl alcohols with alkyl lithium reagents
Jeffrey, Jenna L.,Sarpong, Richmond
, p. 5400 - 5403 (2012)
Direct C(6) alkylation of pyridyl alcohols can be achieved following an initial deprotonation of the hydroxy group. This transformation, which is believed to occur by a Chichibabin-type alkylation, avoids lateral deprotonation prior to pyridine ring alkylation and gives increased regioselectivity for C(6) over C(4) alkylation.