1402928-89-5Relevant articles and documents
DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines
Lamera, Esma,Bouacida, Sofiane,Merazig, Hocine,Chibani, Aissa,Le Borgne, Marc,Bouaziz, Zouhair,Bouraiou, Abdelmalek
, p. 361 - 368 (2017)
A new, convenient, and efficient method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is developed starting from phthalhydrazide, aromatic aldehydes, and malononitrile using 4-N,N-dimethylaminopyridin as catalyst. This modified route provides much higher yields and a simple work-up procedure of products. Also this methodology is of interest due to the use of ethanol as a solvent without use of any toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution.
Mono- and bis-pyrazolophthalazines: Design, synthesis, cytotoxic activity, DNA/HSA binding and molecular docking studies
Hamidinasab, Mahdia,Ameri, Alieh,Hekmat, Azadeh,Forootanfar, Hamid,Mortezazadeh, Tohid,Bodaghifard, Mohammad Ali,Peytam, Fariba,Esmaeili, Rezvan,Foroumadi, Alireza,Sharifzadeh, Mohammad,Mobinikhaledi, Akbar,Khoobi, Mehdi
, (2020/12/25)
In an attempt to find new potent cytotoxic compounds, several mono- and bis-pyrazolophthalazines 4a-m and 6a-h were synthesized through an efficient, one-pot, three- and pseudo five-component synthetic approach. All derivatives were evaluated for their in
Theophylline as a Green Catalyst for the Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones
Mohamadpour, Farzaneh
, p. 64 - 68 (2020/01/25)
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