1403770-36-4Relevant articles and documents
Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids
Arcadi, Antonio,Calcaterra, Andrea,Chiarini, Marco,Fabrizi, Giancarlo,Fochetti, Andrea,Goggiamani, Antonella,Iazzetti, Antonia,Marrone, Federico,Marsicano, Vincenzo,Serraiocco, Andrea
supporting information, p. 741 - 753 (2021/11/26)
The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.
Palladium-catalyzed intermolecular coupling of 3-substituted propargylic carbonates with phenols: Synthesis of 2-substituted benzofuran derivatives
Watanabe, Hirotaka,Okubo, Masataka,Watanabe, Kouichi,Udagawa, Takumi,Kawatsura, Motoi
supporting information, p. 2893 - 2897 (2017/07/11)
We accomplished the synthesis of 2-substituted benzofuran derivatives by the palladium-catalyzed reaction of 3-substituted propargylic carbonates with phenols. The 2-substituted benzofuran derivatives were obtained through the intermolecular coupling of t
Impregnated Copper(II) Oxide on Magnetite as Catalyst for the Synthesis of Benzo[b]furans from 2-Hydroxyarylcarbonyl Derivatives and Alkynes
Pérez, Juana M.,Ramón, Diego J.
, p. 4354 - 4360 (2016/09/14)
The coupling-allenylation-cyclization reaction sequence of o-hydroxybenzaldehydes with alkynes in the presence of 4-methylbenzenesulfonohydrazide was carried out in ethanol as a nontoxic biorenewable solvent and in the presence of impregnated copper(II) oxide on magnetite as a heterogeneous catalyst. The catalyst can be easily removed from the reaction medium by a simple magnetic decantation, and the reaction can be performed with a very low copper loading. The in situ reduction of the starting copper(II) oxide nanoparticles into copper(0) sheets made the recyclability of catalyst impossible. The versatility of the reaction was shown by employing different o-hydroxyacetophenones to give 2,3-disubstituted benzo[b]furans. The reaction can be carried out on a gram scale without any complications.
