1403834-74-1 Usage
General Description
"Fmoc-Cys(STmp)-OH" is a chemical compound consisting of a cysteine amino acid with a special protecting group called S-tritylthiol (STmp) and an Fmoc protecting group. Fmoc-Cys(STmp)-OH is commonly used in the field of peptide chemistry for the synthesis of peptides. The Fmoc protecting group provides stability to the amino acid and can be easily removed under mild conditions, allowing for the selective addition of other amino acids during peptide synthesis. The STmp protecting group, on the other hand, provides protection to the thiol group in cysteine, allowing for controlled and specific reactions in peptide synthesis. Overall, "Fmoc-Cys(STmp)-OH" is a valuable building block in the creation of peptides with specific sequences and functionalities.
Check Digit Verification of cas no
The CAS Registry Mumber 1403834-74-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,3,8,3 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1403834-74:
(9*1)+(8*4)+(7*0)+(6*3)+(5*8)+(4*3)+(3*4)+(2*7)+(1*4)=141
141 % 10 = 1
So 1403834-74-1 is a valid CAS Registry Number.
1403834-74-1Relevant articles and documents
N-Chlorosuccinimide, an efficient reagent for on-resin disulfide formation in solid-phase peptide synthesis
Postma, Tobias M.,Albericio, Fernando
, p. 616 - 619 (2013)
N-Chlorosuccinimide is described as a widely applicable on-resin disulfide-forming reagent. Disulfide bond formation was completed within 15 min in DMF. This strategy was successfully used in the synthesis of oxytocin and a regioselective synthesis of an α-conotoxin. Moreover, disulfide formation with N-chlorosuccinimide was found to be compatible with oxidation-prone methionine and tryptophan.
Trimethoxyphenylthio as a highly labile replacement for tert-butylthio cysteine protection in fmoc solid phase synthesis
Postma, Tobias M.,Giraud, Matthieu,Albericio, Fernando
, p. 5468 - 5471 (2013/01/15)
Trimethoxyphenylthio (S-Tmp) is described as a novel cysteine protecting group in Fmoc solid phase peptide synthesis replacing the difficult to remove tert-butylthio. S-Tmp and dimethoxyphenylthio (S-Dmp) were successfully used for cysteine protection in a variety of peptides. Moreover, both groups can be removed in 5 min with mild reducing agents. S-Tmp is recommended for cysteine protection, as it yields crude peptides of high purity.
