140425-65-6

Basic information

• Product Name: Benzonitrile, 2-[(2-aminophenyl)thio]-
• CAS NO: 140425-65-6
• Molecular Formula: C13H10N2S
• Molecular Weight: 226.302
• Mol File: 140425-65-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-[(2-aminophenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-[(2-aminophenyl)thio]-(140425-65-6)
• EPA Substance Registry System: Benzonitrile, 2-[(2-aminophenyl)thio]-(140425-65-6)

Safety Data

• Hazardous Substances Data: 140425-65-6(Hazardous Substances Data)

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 137-07-5 2-amino-benzenethiol 
• 4387-36-4 2-iodobenzonitrile 
• 874-05-5 3-aminoindazole 
• 873-32-5 2-Chlorobenzonitrile 

Downstream Products

• 151079-71-9 2-mercapto 2'-cyanodiphenylamine 
• 3159-07-7 dibenzo[b,f][1,4]thiazepin-11-one 
• 151079-74-2 2-(2'-cyanophenylaminophenyl)disulfide 
• 5786-26-5 11-aminodibenzo<1,4>thiazepine 

Relevant articles and documents

Synthesis of 11-Aminodibenzo[b,f][1,4]thiazepines and Fluoro Derivatives

The reaction of halogenobenzonitriles with 2-aminobenzenethiol is a new route, in a "one-pot" or two-step approach, to 11-aminodibenzo[b,f][1,4]thiazepine and fluoro derivatives.

Facile synthesis of 1,2-thiobenzonitriles: Via Cu-catalyzed denitrogenative radical coupling reaction

A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C-N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenative radical coupling with 3-aminoindazoles.

Antiviral dibenzothiazepinone derivatives

Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6 alkyl, C3-6 cycloalkyl or C1-6 alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); --NR4 R5 where R4 and R5, which may be the same or different, each represent hydrogen or C1-6 alkyl; --S(O)m R6, where m is 0, 1, 2 or 3 and R6 represents hydrogen, C1-6 alkyl or C3-6 cycloakyl; --SO2 NR4 R5 where R4 et R5 are each as defined above; phenyl, phenylC1-3 alkoxy or phenylC1-3 alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and --CO2 H or --COR7 where R7 is C1-6 alkyl or C3-6 cycloalkyl; R3 represents hydrogen or C1-4 alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.