1404304-74-0Relevant articles and documents
Diastereoselective formation of tetrahydrofurans via pd-catalyzed asymmetric allylic alkylation: Synthesis of the C13-C29 subunit of amphidinolide N
Trost, Barry M.,Rey, Jullien
, p. 5632 - 5635 (2013/01/15)
An efficient synthesis of the C13-C29 fragment of amphidinolide N is described. The synthesis relies on a new strategy involving Pd-catalyzed asymmetric allylic alkylation to generate diastereoselectively the cis- or trans-THF unit simply by varying the enantiomer of the ligand. The C19 hydroxyl-bearing stereocenter was introduced using a chelation-controlled allylation which led exclusively to a single diastereoisomer.
