1404367-02-7Relevant articles and documents
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a ]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability
Hu, Qingzhong,Yin, Lina,Ali, Amjad,Cooke, Andrew J.,Bennett, Jonathan,Ratcliffe, Paul,Lo, Michael Man-Chu,Metzger, Edward,Hoyt, Scott,Hartmann, Rolf W.
, p. 2530 - 2537 (2015)
CYP11B2 inhibition is a promising treatment for diseases caused by excessive aldosterone. To improve the metabolic stability in human liver miscrosomes of previously reported CYP11B2 inhibitors, modifications were performed via a combination of ligand-and