140613-57-6

Basic information

• Product Name: (2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
• Synonyms: (2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
• CAS NO: 140613-57-6
• Molecular Formula: C₃₉H₄₈N₅O₇P
• Molecular Weight: 0
• Mol File: 140613-57-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(140613-57-6)
• EPA Substance Registry System: (2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(140613-57-6)

Safety Data

• Hazardous Substances Data: 140613-57-6(Hazardous Substances Data)

Usage

Description

(2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is a complex organic compound with a tetrahydrofuran backbone and various functional groups. It features a 4-amino-2-oxopyrimidin-1(2H)-yl group and a 2-cyanoethyl diisopropylphosphoramidite group, as well as bis(4-methoxyphenyl)(phenyl)methoxy methyl groups attached to the tetrahydrofuran ring. This unique structure is significant in organic synthesis, particularly for nucleotide and peptide synthesis, due to its ability to protect and release specific functional groups during the synthesis of oligonucleotides and peptides.

Uses

Used in Organic Synthesis:
(2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is used as a protecting and releasing agent in the synthesis of nucleotides and peptides. Its unique structure allows for the protection of specific functional groups during the synthesis process, enabling the creation of complex oligonucleotides and peptides with greater precision and efficiency.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, this compound is utilized as a key intermediate in the development of new drugs, particularly those targeting nucleic acid-based therapies. Its ability to protect and release functional groups makes it a valuable tool in the synthesis of potential therapeutic agents, such as antisense oligonucleotides and small interfering RNAs (siRNAs), which have applications in treating various diseases, including genetic disorders and cancer.
Used in Research and Development:
(2R,3S,5R)-5-(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is also employed in research and development settings, where it serves as a valuable reagent for studying the synthesis and properties of nucleotides and peptides. Its unique structure and functional groups make it an important tool for understanding the fundamental principles of organic synthesis and the development of new synthetic strategies.

Upstream product

• 129452-87-5 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide 
• 398148-63-5 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[2-oxo-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 139036-59-2 4-N-[2-(tert-butyldiphenylsilyloxymethyl)]benzoyl deoxycytidine 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 157543-67-4 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 
• 116003-04-4 N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 76512-82-8 5'-O-(4,4'-dimethoxytrityl)deoxycytidine 
• 129452-90-0 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 951-77-9 2'-Deoxycytidine 
• 51432-42-9 4-Amino-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one 

Downstream Products

• 4829-64-5 2'-deoxycytidylyl-(3',5')-thymidine phosphate 
• 116003-04-4 N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite 
• 77710-60-2 2'-deoxycytosylyl-(3',5')-thymidine ammonium salt 

Relevant articles and documents

BIOINK GEL FORMULATIONS COMPRISING NUCLEOLIPID-BASED COMPOUND

The present invention relates to nucleolipid-based compounds for use in regenerative medicine. More specifically, the invention relates to the use of to nucleolipid-based compounds in bioink gel formulations and a bioprinting method comprising the use of

Oligonucleotide with protected base

The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

OLIGONUCLEOTIDE WITH PROTECTED BASE

The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.