14064-34-7

Basic information

• Product Name: 4-aminobutane-1-sulfonic acid
• CAS NO: 14064-34-7
• Molecular Formula: C₄H₁₁NO₃S
• Molecular Weight: 153.2
• Mol File: 14064-34-7.mol
• Article Data: 4

Chemical Properties

• Density: 1.311g/cm³
• Refractive Index: 1.503
• CAS DataBase Reference: 4-aminobutane-1-sulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aminobutane-1-sulfonic acid(14064-34-7)
• EPA Substance Registry System: 4-aminobutane-1-sulfonic acid(14064-34-7)

Safety Data

• Hazardous Substances Data: 14064-34-7(Hazardous Substances Data)

Upstream product

• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 110-52-1 1,4-dibromo-butane 
• 37441-50-2 1,4-butanesultam 
• 14369-05-2 Benzaldehyd-<4-sulfobutyl-hydrazon> 
• 1633-83-6 1,4-butane sultone 

Downstream Products

• 113811-48-6 N-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-4-aminobutanesulfonic acid 

Relevant articles and documents

15 the position escapes acetylprotoaescigenin 13 bit linear amino sulfonic acid substituted hypocrellin derivative and its preparation method and application

The invention discloses a site-15 deacetylation and site-13 straight-chain sulfamic acid substituted hypocrellin derivative, a preparation method and application thereof. The structural general formula of the derivative is shown as the formula I (disclosed in the specification). The derivative is a novel hypocrellin derivative designed specially aiming at photodynamic medical treatment of micrangium diseases such as related retina macular degeneration, and the like. The maximum light absorption wavelength of the derivative is 58 nm, and the light tissue penetration depth in the wavelength range conforms to the focus depth of the micrangium diseases, meanwhile, the absorption spectrum of visual pigment is kept away as far as possible; and in addition, the derivative has optimized dual affiliation to fat and water and can be directly dissolved into normal saline to prepare intravenous injection solutions without complicated preparation technologies.

Methotrexate analogues. 32. Chain extension, α-carboxyl deletion, and γ-carboxyl replacement by sulfonate and phosphonate: Effect on enzyme binding and cell-growth inhibition

Analogues of methotrexate (MTX) and aminopterin (AMT) with aminophosphonoalkanoic, aminoalkanesulfonic, and aminoalkanephosphonic acid side chains in place of glutamate were synthesized and tested as inhibitors of folylpolyglutamate synthetase (FPGS) from mouse liver. The aminophosphonoalkanoic acid analogues were also tested as inhibitors of dihydrofolate reductase (DHFR) from L1210 murine leukemia cells and as inhibitors of the growth of MTX-sensitive (L1210) and MTX-resistant (L1210/R81) cells in culture. The optimal number of CH2 groups in aminophosphonoalkanoic acid analogues of AMT was found to be two for both enzyme inhibition and cell growth inhibition but was especially critical for activity against FPGS. Deletion of the α-carboxyl also led to diminished anti-FPGS activity in comparison with previously studied homocysteic acid and 2-amino-4-phosphonobutyric acid analogues. In the aminoalkanesulfonic acid analogues of MTX without an α-carboxyl, anti-FPGS activity was low and showed minimal variation as the number of CH2 groups between the carboxamide and sulfonate moieties was changed from one to four. In similar aminoalkanephosphonic acid analogues of MTX, anti-FPGS activity was also low, was comparable for two and three CH2 groups between the carboxamide and phosphonate moieties, and was diminished by monoesterification of the phosphonate group. These effects demonstrate that the α-carboxyl group of folate analogues is involved in binding to the active site of FPGS, and that an α-carboxyl group should be retained as part of the structure of FPGS inhibitors.