140647-02-5Relevant articles and documents
Synthesis of benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines as DNA-binding and potential anticancer agents
Kamal, Ahmed,Rajender,Reddy, Methuku Kashi,Reddy, Vangala Santhosh,Kumar, Gajjela Bharath
, p. 177 - 192 (2013/07/28)
A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.
Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
Kamal, Ahmed,Balakishan,Ramakrishna,Basha Shaik,Sreekanth,Balakrishna,Rajender,Dastagiri,Kalivendi, Shasi V.
experimental part, p. 3870 - 3884 (2010/09/14)
A series of new cinnamido-pyrrolo[2,1-c][1,4]benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited signif
Synthesis of C8-C8/C2-C8-linked triazolo pyrrolobenzodiazepine dimers by employing 'click' chemistry and their DNA-binding affinity
Kamal, Ahmed,Prabhakar,Shankaraiah,Reddy, Ch. Ratna,Reddy, P. Venkat
, p. 3620 - 3624 (2008/09/21)
A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-c