140660-29-3

Basic information

• Product Name: Benzonitrile, 3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-
• CAS NO: 140660-29-3
• Molecular Formula: C17H15NO3
• Molecular Weight: 281.311
• Mol File: 140660-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-(140660-29-3)
• EPA Substance Registry System: Benzonitrile, 3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-(140660-29-3)

Safety Data

• Hazardous Substances Data: 140660-29-3(Hazardous Substances Data)

Upstream product

• 2896-60-8 4-ethyl-1,3-benzenediol 
• 6952-59-6 3-cyanobromobenzene 
• 4460-42-8 1-(5-ethyl-2,4-dihydroxyphenyl)ethanone 

Relevant articles and documents

Leukotriene B4 Receptor Antagonists: The LY255283 Series of Hydroxyacetophenones

A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-oxy>phenyl>ethanone (compound 35, LY255283).Using an assay for inhibition of specific LTB4 binding to human PMN, we found that substitution of a nonpolar substituent in the 5-position was required for activity.Best activity was realized with hydrogen in the 3-position, hydroxyl in the 2-position, short chain alkyl ketone in the 1-position, and a six- or eight-carbon chain linking the oxygen in the 4-position with an unsaturated terminal function.Compound 35, having an IC50 of 87 nM in the binding assay, was chosen for further preclinical evaluation.