1407-47-2

Basic information

• Product Name: Angiotensin
• Synonyms: ANGIOTENSIN;ANGIOTENSINII, HYPERTENSIN;Hypertensin
• CAS NO: 1407-47-2
• Molecular Formula: C62H89N17O14
• Molecular Weight: 1296.49
• EINECS: 215-804-9
• Product Categories: Amino Acid Derivatives;enzyme
• Mol File: 1407-47-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: powder
• Density: 1.48g/cm³
• Refractive Index: 1.679
• CAS DataBase Reference: Angiotensin(CAS DataBase Reference)
• NIST Chemistry Reference: Angiotensin(1407-47-2)
• EPA Substance Registry System: Angiotensin(1407-47-2)

Safety Data

• Hazardous Substances Data: 1407-47-2(Hazardous Substances Data)

Usage

Description

Angiotensin is a peptide found in the blood, which plays a crucial role in regulating blood pressure. It is composed of either ten or eight amino acids, known as a decapeptide and an octapeptide, respectively. The complete structures of these peptides have been established, and they are essential for maintaining proper blood pressure levels in the body.

Uses

Used in Pharmaceutical Industry:
Angiotensin is used as a therapeutic agent for the treatment of hypertension and other cardiovascular conditions. Its primary function is to constrict blood vessels, which in turn increases blood pressure. This makes it a valuable compound in the development of medications aimed at managing high blood pressure and related health issues.
Used in Research and Development:
Angiotensin is also utilized in research and development for understanding the complex mechanisms behind blood pressure regulation and cardiovascular health. By studying the effects of angiotensin on blood pressure, scientists can gain insights into the development of new drugs and therapies for various cardiovascular diseases.
Used in Diagnostic Applications:
Angiotensin can be used as a diagnostic marker to assess the risk of developing hypertension or other cardiovascular conditions. By measuring the levels of angiotensin in a patient's blood, healthcare professionals can identify potential issues and take appropriate preventive measures or initiate treatment.

Safety Profile

Poison by intravenous route. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes.

InChI:InChI=1/C48H67N15O12/c1-27(2)41(62-44(72)32(58-37(65)21-49)10-6-16-53-48(50)51)46(74)61-34(19-29-12-14-31(64)15-13-29)43(71)56-24-39(67)59-35(20-30-22-52-26-57-30)47(75)63-17-7-11-36(63)45(73)60-33(18-28-8-4-3-5-9-28)42(70)55-23-38(66)54-25-40(68)69/h3-5,8-9,12-15,22,26-27,32-36,41,64H,6-7,10-11,16-21,23-25,49H2,1-2H3,(H,52,57)(H,54,66)(H,55,70)(H,56,71)(H,58,65)(H,59,67)(H,60,73)(H,61,74)(H,62,72)(H,68,69)(H4,50,51,53)/t32-,33-,34-,35-,36-,41-/m0/s1

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Angiotensin (cas 1407-47-2) receptor expression revealed by reporter mice and beneficial effects of AT2R agonist in retinal cells09/29/2019

The renin-angiotensin system (RAS) plays a vital role in cardiovascular physiology and body homeostasis. In addition to circulating RAS, a local RAS exists in the retina. Dysfunction of local RAS, resulting in increased levels of Angiotensin II (Ang II) and activation of AT1R-mediated signaling ...detailed

Angiotensin (cas 1407-47-2) II type 2 receptor and Angiotensin (cas 1407-47-2)-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats09/28/2019

AimDepressor arm of the renin-angiotensin system (RAS) exerts reno-protective effects in chronic kidney diseases like diabetic nephropathy. However, same is still elusive under AKI and hyperglycaemia comorbidity. Hence, the present study delineates the role of angiotensin-II type 2 receptor (AT2...detailed

Clinical InvestigationT-Lymphocyte-Based Renin Angiotensin (cas 1407-47-2) System in Obesity10/01/2019

ABSTRACTBackgroundObesity can be associated with increased cardio-metabolic risk, but some subjects with obesity do not show metabolic impairment and escape this association. Low-grade inflammation (i.e., high sensitivity C-reactive protein [hsCRP] > 3 mg/dL) is associated with high cardiovascul...detailed

Roles of I2PP2A in the downregulation of eNOS Ser1177 phosphorylation by Angiotensin (cas 1407-47-2) II-activated PP2A09/25/2019

The chronic elevation of angiotensin II (Ang II) is an important cause of endothelial dysfunction (ED). The Ang II/type 1 receptor (AT1R) signaling pathway can cause endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) dysfunction through various mechanisms leading to ED. The modulation of...detailed

Angiotensin (cas 1407-47-2) II and aldosterone in retinal vasculopathy and inflammation09/24/2019

Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal disease. The localization of RAAS components within the retina has led to studies investigating the roles of angiot...detailed