1407814-92-9

Basic information

• Product Name: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine
• Synonyms: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine
• CAS NO: 1407814-92-9
• Molecular Weight: 227.241
• Mol File: 1407814-92-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine(1407814-92-9)
• EPA Substance Registry System: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine(1407814-92-9)

Safety Data

• Hazardous Substances Data: 1407814-92-9(Hazardous Substances Data)

Upstream product

• 1228788-25-7 pyridazin-3-ylmethanamine hydrochloride 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 451-81-0 2-(2-fluorophenyl)acetyl chloride 
• 1407814-85-0 2-(2-fluorophenyl)-N-[(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)methyl]acetamide 
• 79416-27-6 methyl aminolevulinate 
• 920285-96-7 C₅H₉N₃O 
• 1352906-01-4 2-chloro-7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine 

Downstream Products

• 1407814-95-2 5-bromo-7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine 
• 1407815-02-4 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate 
• 1407814-98-5 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile 

Relevant articles and documents

Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947

The NO-sGC-cGMP signaling pathway plays an important role in the cardiovascular system. Loss of nitric oxide tone or impaired signaling has been associated with cardiovascular diseases, such as hypertension, pulmonary hypertension and heart failure. Direct activation of sGC enzyme independent of NO represents a novel approach for modulating NO signaling with tremendous therapeutic potential. Herein, we describe the design of a structurally novel class of heme-dependent sGC stimulators containing the 3,3-dimethylpyrrolidin-2-one moiety which resulted in the identification of the potent, selective stimulator 30 (MK-2947) for the treatment of hypertension.

SUBSTITUTED AZABICYCLES AND USE THEREOF

The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF

The present application relates to novel substituted imidazopyridines and imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.