1407858-88-1 Usage
Description
2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid is a chemical compound that features a five-membered heterocyclic ring with both oxygen and nitrogen atoms. It is an oxazole derivative characterized by the presence of a carboxylic acid functional group. 2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid can be synthesized through various methods and is known for its potential applications in the pharmaceutical industry and organic chemistry. Its structural features and possible biological activities make it a valuable component in medicinal chemistry and drug discovery. Additionally, it serves as a building block for the synthesis of more complex organic molecules.
Uses
Used in Pharmaceutical Industry:
2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid is utilized as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows it to be a key component in creating molecules with specific therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid is used as a structural element in the design and synthesis of potential drug candidates. Its incorporation can enhance the pharmacological profile of new compounds, contributing to improved efficacy and selectivity.
Used in Drug Discovery:
2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid plays a role in drug discovery as a component of screening libraries. Its presence in these libraries allows researchers to explore its potential in various biological assays, leading to the identification of new lead compounds for further development.
Used as a Building Block in Organic Synthesis:
Beyond its pharmaceutical applications, 2,3-dihydro-2-oxo-5-Oxazolecarboxylic acid is also used as a building block in the synthesis of more complex organic molecules. Its reactivity and structural characteristics make it a versatile component in organic chemistry for creating a wide range of compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1407858-88-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,7,8,5 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1407858-88:
(9*1)+(8*4)+(7*0)+(6*7)+(5*8)+(4*5)+(3*8)+(2*8)+(1*8)=191
191 % 10 = 1
So 1407858-88-1 is a valid CAS Registry Number.
1407858-88-1Relevant articles and documents
Development of autotaxin inhibitors: A series of zinc binding triazoles
Thomson, Christopher G.,Le Grand, Darren,Dowling, Mark,Brocklehurst, Cara E.,Chinn, Colin,Elphick, Lucy,Faller, Michael,Freeman, Mark,Furminger, Vikki,Gasser, Cornelia,Hamadi, Ahmed,Hardaker, Elizabeth,Head, Victoria,Hill, Johan C.,Janus, Diana I.,Pearce, David,Poulaud, Anne-Sophie,Stanley, Emily,Sviridenko, Lilya
supporting information, p. 2279 - 2284 (2018/05/24)
A series of inhibitors of Autotaxin (ATX) has been developed using the binding mode of known inhibitor, PF-8380, as a template. Replacement of the benzoxazolone with a triazole zinc-binding motif reduced crystallinity and improved solubility relative to PF-8380. Modification of the linker region removed hERG activity and led to compound 12 – a selective, high affinity, orally-bioavailable inhibitor of ATX. Compound 12 concentration-dependently inhibits autotaxin and formation of LPA in vivo, as shown in pharmacokinetic-pharmacodynamic experiments.
Autotaxin inhibitors
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Page/Page column, (2014/06/25)
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
