1407973-55-0Relevant articles and documents
Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4
Bai, Renren,Liu, Jie,Zhu, Yao,Yang, Xue,Yang, Chen,Kong, Lingyi,Wang, Xiaobing,Zhang, Hengyuan,Yao, Hequan,Shen, Mingqin,Wu, Xiaoming,Xu, Jinyi
, p. 6490 - 6493 (2012/11/07)
(±)-7,8-Dihydroxy-3-methyl-isochromanone-4 [(±)-XJP] is a natural antihypertensive product contained in banana (Musa sapientum L.) peel. (-)-XJP and (+)-XJP were first obtained by chiral resolution, meanwhile circular dichroism (CD) calculations and chiral synthesis were employed to investigate the absolute configuration. The results indicated that the absolute configuration of (+)-XJP is S-configured and the absolute configuration of (-)-XJP is R-configured. Furthermore, the evaluation of antihypertensive effects in vivo proved that R-(-)-XJP was more potent than S-(+)-XJP and [(±)-XJP].