1408382-14-8

Basic information

• Product Name: (4S)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one
• Synonyms: (4S)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one
• CAS NO: 1408382-14-8
• Molecular Weight: 223.274
• Mol File: 1408382-14-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one(1408382-14-8)
• EPA Substance Registry System: (4S)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one(1408382-14-8)

Safety Data

• Hazardous Substances Data: 1408382-14-8(Hazardous Substances Data)

Upstream product

• 4410-32-6 N-benzyl-2-hydroxy-2-phenylacetamide 
• 81384-43-2 2-(benzylamino)-2-oxo-1-phenylethyl acetate 
• 100-46-9 benzylamine 
• 51019-43-3 (R)-(-)-O-acetylmandelic acid 
• 1408381-69-0 (2R)-N-benzyl-2-chloro-2-phenylethanamide 
• 1408381-65-6 (1R)-2-(benzylamino)-2-oxo-1-phenylethyl methanesulfonate 
• 88393-58-2 (R)-N-benzyl-2-hydroxy-2-phenylacetamide 

Relevant articles and documents

A new chemoenzymatic approach to the synthesis of chiral 4-aryl-1,4-dihydro-2H-isoquinolines via the enzymatic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3-one

A new chemoenzymatic method is proposed for the synthesis of enantiomerically pure 4-phenyl-1,4-dihydro-2H-isoquinolines based on the enzymatic kinetic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3- one. For the enzymatic resolution of the racemic substrate, readily available 'home made' animal liver acetone powders (LAPs) were used. Excellent enantioselectivity, exceeding 500, was achieved in a short reaction time upon application of turkey liver acetone powder as the biocatalyst. Reduction of obtained product led to the formation of amine (R)-1, which is hardly available using standard procedures. These results show that N-acetyl lactams are a new type of substrate for enzymatic biotransformations.