14087-87-7

Basic information

• Product Name: 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one
• Synonyms: 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one
• CAS NO: 14087-87-7
• Molecular Weight: 242.705
• Mol File: 14087-87-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one(14087-87-7)
• EPA Substance Registry System: 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one(14087-87-7)

Safety Data

• Hazardous Substances Data: 14087-87-7(Hazardous Substances Data)

Upstream product

• 5172-02-1 1-chloro-4-(2-phenylethynyl)benzene 
• 201230-82-2 carbon monoxide 
• 1283152-85-1 (E)-2-[2-(4-chlorophenyl)ethenyl]benzaldehyde 
• 1073-67-2 4-vinylbenzyl chloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 100-44-7 benzyl chloride 
• 1878-66-6 4-chlorophenylacetic Acid 
• 787-27-9 (±)-2-(4-chlorophenyl)-3-phenylpropanoic acid 

Downstream Products

• 14087-99-1 2-(4-Chloro-phenyl)-indan-1-ol 
• 47647-40-5 (2-{4-[2-(4-Chloro-phenyl)-indan-1-yl]-phenoxy}-ethyl)-diethyl-amine 
• 14087-82-2 4-[2-(4-Chloro-phenyl)-indan-1-yl]-phenol 

Relevant articles and documents

Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones

The intramolecular hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of additional substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asymmetric version has not been considered possible due to problems associated with the racemization of the products. We have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramolecular hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asymmetric variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.