14088-82-5

Basic information

• Product Name: 1,2-Ethanediamine, N-(2-chlorophenyl)-
• CAS NO: 14088-82-5
• Molecular Formula: C8H11ClN2
• Molecular Weight: 170.642
• Mol File: 14088-82-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediamine, N-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediamine, N-(2-chlorophenyl)-(14088-82-5)
• EPA Substance Registry System: 1,2-Ethanediamine, N-(2-chlorophenyl)-(14088-82-5)

Safety Data

• Hazardous Substances Data: 14088-82-5(Hazardous Substances Data)

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 137-04-2 2-chloroaniline hydrochloride 

Downstream Products

• 1096969-15-1 C₉H₉ClN₂S 
• 86140-64-9 1-(Indazol-4-yloxy)-3-[2-(2-chlorophenylamino)-ethylamino]-propan-2-ol 
• 71314-08-4 3-[β-(2-chlorophenylamino)-ethyl]-amino-2-hydroxy-1-phenoxypropane 
• 61797-07-7 Undec-10-enoic acid (2-chloro-phenyl)-(2-undec-10-enoylamino-ethyl)-amide 

Relevant articles and documents

Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives.

A series of benzoylpiperidine analogs related to 4a was prepared, and their ability to inhibit the uptake of [(14)C]-glycine in COS7 cells transfected with human glycine transporter type-2 (GlyT-2) was evaluated. Small structural changes to the benzoylpiperidine region of the molecule led to a significant decrease in GlyT-2 inhibitory activity. In contrast, the distal aryl ring was more tolerant to functional group modifications and could accommodate a variety of substitutes at the C-2 or C-3 positions. Comparable activities to 4a were obtained by replacing the anilino nitrogen with an ether linkage 27 or by exchanging the isopropoxy ether moiety with an isopropyl amino group 15. A distinct preference for a 2-carbon tether (n=1) was observed relative to the corresponding 3-carbon homolog (n=2).

Aminoethylation process

2-Oxazolidinone or N-substituted derivatives thereof are reacted with aromatic amine hydrochlorides at elevated temperatures to produce 1,2-ethanediamines.