14091-15-7Relevant articles and documents
Schwyzer,Surbeck-Wegmann
, p. 1073,1075 (1960)
Method for synthesizing 4-bromo-D-phenylalanine
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, (2020/03/14)
The invention discloses a method for synthesizing 4-bromo-D-phenylalanine. The method comprises the following steps: adding diethyl acetylaminomalonate, sodium ethoxide and ethanol into a reaction bottle, heating the reaction bottle to 80 DEG C, performing a heat insulation reaction for 2 h, cooling the reaction bottle to 35 DEG C, adding 4-bromobenzyl bromide, performing a heat insulation reaction for 5 h, cooling the reaction bottle to 25 DEG C, performing reduced pressure concentrating crystallization to obtain diethyl (acetylamino)[(4-bromophenyl)methyl]malonate, adding sodium hydroxide, heating the reaction bottle to 45 DEG C, performing a heat insulation reaction for 4 h, and cooling the reaction bottle to 20 DEG C to achieve crystallization in order to obtain (acetylamino)[(4-bromophenyl)methyl]malonic acid; and adding a 60% W/V hydrochloric acid solution, heating the reaction bottle to 85 DEG C, keeping the temperature for 2 h, ending the obtained reaction, and performing concentrating crystallization to obtain the 4-bromo-D-phenylalanine. Compared with traditional technologies, the method in the invention has the advantages of mild reaction temperature, safety in operation, obtaining of the highly pure product, cheap and easily-available raw materials, and very low cost.
Enhanced reduction of C-N multiple bonds using sodium borohydride and an amorphous nickel catalyst
Liu, Shouxin,Yang, Yihua,Zhen, Xiaoli,Li, Junzhang,He, Huimin,Feng, Juan,Whiting, Andrew
experimental part, p. 663 - 670 (2012/01/15)
Amorphous nickel powder (Ni0) was utilised as a catalyst under mild, aqueous, basic conditions for enhancing the sodium borohydride-mediated reduction of C-N multiple bonds such as oximes, imines, hydrazones and nitriles to produce the corresponding amines in good to excellent yields.
