141-01-5 Usage
Description
Ferrous fumarate is the ferrous salt form of fumarate, an anhydrous salt of a combination of ferrous iron and fumaric acid. It is a stable, odorless, and substantially tasteless reddish-brown powder that contains approximately 33% iron by weight. Ferrous fumarate is insoluble in alcohol and does not melt at temperatures up to 280°C. It is a commonly used inexpensive substitute for other forms of iron and is employed as a food iron fortificant.
Uses
1. Used in Pharmaceutical Applications:
Ferrous fumarate is used as an iron supplement for the treatment of iron deficiency and anemia. It has been demonstrated that the application of ferrous fumarate, in combination with ascorbic acid, results in successful treatment of anemia without remarkable side effects.
2. Used in Food Industry:
Ferrous fumarate is used as a dietary supplement in various food products, such as breakfast cereals, poultry stuffing, enriched flour, and instant drinks. It has high bioavailability and can be used in foods where the red color can be masked.
3. Used in Animal Feed Industry:
Ferrous fumarate is used as an additive in animal feed to provide essential iron for the health and well-being of animals.
4. Used in Infant Formulas:
Ferrous fumarate is also used in infant formulas to ensure that infants receive adequate iron for proper growth and development.
5. Used in Quality Control in Pharmaceutical Laboratories:
Ferrous fumarate serves as a pharmaceutical secondary standard for application in quality control, providing a convenient and cost-effective alternative to the preparation of in-house working standards.
Originator
Toleron,Mallinckrodt Inc.,US,1957
Manufacturing Process
Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to
45 gallons) and fumaric acid (50 pounds) was added slowly. During the
addition the solution was stirred and heated. The resulting solution of sodium
fumarate, having a pH of 6.8, was added slowly with mixing to a solution of
ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH
of 3.3, both solutions being maintained at or near boiling temperature during
the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate
was filtered and washed in a centrifuge and dried in a tray drier (15 hours at
110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe,
32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.
Therapeutic Function
Hematinic
Flammability and Explosibility
Notclassified
Clinical Use
Iron deficiency anaemia
Safety Profile
Poison by
intraperitoneal route. Moderately toxic by
ingestion and subcutaneous routes. Human
systemic effects by ingestion: dyspnea,
nausea or vomiting, somnolence. When
heated to decomposition it emits acrid
smoke and irritating fumes. See also
FUMRIC ACID.
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: reduced absorption of 4-quinolones
and tetracyclines.
Dimercaprol: avoid concomitant use.
Mycophenolate: may significantly reduce absorption
of mycophenolate.
Metabolism
Molecular weight (daltons) 169.9
% Protein binding -
% Excreted unchanged in urine -
Volume of distribution (L/kg) -
Half-life - normal/ESRF (hrs) -
References
Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.
Check Digit Verification of cas no
The CAS Registry Mumber 141-01-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 141-01:
(5*1)+(4*4)+(3*1)+(2*0)+(1*1)=25
25 % 10 = 5
So 141-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2
