1410075-22-7

Basic information

• Product Name: 2-benzyhydrylsulfinyl-N-cyclohexylacetamide
• Synonyms: 2-benzyhydrylsulfinyl-N-cyclohexylacetamide
• CAS NO: 1410075-22-7
• Molecular Weight: 355.501
• Mol File: 1410075-22-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyhydrylsulfinyl-N-cyclohexylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyhydrylsulfinyl-N-cyclohexylacetamide(1410075-22-7)
• EPA Substance Registry System: 2-benzyhydrylsulfinyl-N-cyclohexylacetamide(1410075-22-7)

Safety Data

• Hazardous Substances Data: 1410075-22-7(Hazardous Substances Data)

Upstream product

• 118286-19-4 (diphenylmethyl)(ethyl acetate)sulfoxide 
• 91-01-0 1,1-Diphenylmethanol 
• 63547-22-8 (benzhydrylthio)acetic acid 
• 108-91-8 cyclohexylamine 
• 63547-24-0 modafinil acid 

Relevant articles and documents

Simple synthesis of modafinil derivatives and their anti-inflammatory activity

Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling reactions. We determined the anti-inflammatory effects of modafinil derivatives in cultured BV2 cells by measuring the inhibition of nitrite production and expression of iNOS and COX-2 after LPS stimulation. It was found that for sulfide analogues introduction of aliphatic groups on the amide part (compounds 11a-d) resulted in lower anti-inflammatory activity compared with cyclic or aromatic moieties (compounds 11e-k). However, for the sulfoxide analogues, introduction of aliphatic moieties (compounds 12a-d) showed higher anti-inflammatory activity than cyclic or aromatic fragments (compounds 12e-k) in BV-2 microglia cells.