14101-04-3

Basic information

• Product Name: FRANGULIN B
• Synonyms: EMODIN-6-(L)-O-APIOSIDE;EMODIN-L-RHAMNOSIDE;EMODIN-6-O-APIOSIDE;FRANGULIN B;RAHMNOXANTHIN;3-(D-apio-.betascsc.-furanosyloxy)-1,8-dihydroxy-6-methylanthraquinone;3-(D-Apio-β-D-furanosyloxy)-1,8-dihydroxy-6-methyl-9,10-anthracenedione;3-(D-Apio-beta-D-furanosyloxy)-1,8-dihydroxy-6-methylanthraquinone
• CAS NO: 14101-04-3
• Molecular Formula: C20H18O9
• Molecular Weight: 402.35
• EINECS: 237-953-9
• Product Categories: Anthraquinones, Hydroquinones and Quinones
• Mol File: 14101-04-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 196℃
• Boiling Point: 781.4°Cat760mmHg
• Flash Point: 282.4°C
• Appearance: /
• Density: 1.655±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 3E-25mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 2-8°C
• PKA: 6.01±0.20(Predicted)
• CAS DataBase Reference: FRANGULIN B(CAS DataBase Reference)
• NIST Chemistry Reference: FRANGULIN B(14101-04-3)
• EPA Substance Registry System: FRANGULIN B(14101-04-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 14101-04-3(Hazardous Substances Data)

Usage

Description

FRANGULIN B, an anthraquinone derivative, is a natural product derived from Formosan plants. It possesses anti-inflammatory properties and has been recognized for its potential as an inhibitor of DNA Methyltransferase, making it a promising candidate for various applications in the pharmaceutical and biotechnology industries.

Uses

Used in Pharmaceutical Applications:
FRANGULIN B is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate symptoms associated with various conditions. Its natural origin and potential to modulate immune responses make it a valuable asset in the development of novel therapeutics.
Used in Epigenetic Regulation:
FRANGULIN B is used as an inhibitor of DNA Methyltransferase for its potential to regulate gene expression and influence cellular processes. By targeting DNA Methyltransferase, FRANGULIN B may play a role in the treatment of diseases with epigenetic components, such as cancer.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, given FRANGULIN B's role as an inhibitor of DNA Methyltransferase, it can be inferred that it may also be used as an anticancer agent. This application would involve targeting the epigenetic changes that contribute to the development and progression of cancer, potentially leading to novel therapeutic strategies for cancer treatment.
Used in Drug Delivery Systems:
While not specifically mentioned in the materials, the potential applications of FRANGULIN B in drug delivery systems could be explored. Similar to gallotannin, the development of novel drug delivery systems for FRANGULIN B could enhance its bioavailability, delivery, and therapeutic outcomes, particularly in the context of its anti-inflammatory and epigenetic regulation properties.

InChI:InChI=1/C20H18O9/c1-8-2-10-14(12(22)3-8)17(25)15-11(16(10)24)4-9(5-13(15)23)29-19-18(26)20(27,6-21)7-28-19/h2-5,18-19,21-23,26-27H,6-7H2,1H3/t18-,19-,20+/m0/s1