141113-41-9

Basic information

• Product Name: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL
• Synonyms: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL;(R)-2-(2,4-difluoro-phenyl)-3-[1H-1,2,4]triazoll-1-yl-propane-1,2-diol;(R)-2-(2,4-Difluorophenyl)-3-[1H-1,2,4]triazol-1-ylpropane-1,2-diol
• CAS NO: 141113-41-9
• Molecular Formula: C₁₁H₁₁F₂N₃O₂
• Molecular Weight: 255.22
• Mol File: 141113-41-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL(141113-41-9)
• EPA Substance Registry System: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL(141113-41-9)

Safety Data

• Hazardous Substances Data: 141113-41-9(Hazardous Substances Data)

Usage

General Description

"(R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL" is a complex chemical compound that incorporates multiple functional groups, including a fluorine-substituted phenyl group, an 1,2,4-triazole group, and a propanediol backbone. The (R) denotes that the compound is the R-enantiomer, referring to the specific spatial configuration of its atoms. Flurofenyl group present in the compound signifies the presence of fluorine atoms which often contribute to the stability of the compound. The triazole part suggests that it may have potential biological activity, as many triazole compounds are used in medicinal chemistry due to their ability to bond with a variety of biological targets. In summary, without the specific context or use, we can anticipate that this compound can be used in multiple domains, including pharmaceuticals, where such complex compounds are common. However, specific properties, its uses, toxicity, and other details will require additional information or study.

Upstream product

• 86386-74-5 1,3-(dichloro)-2-(2,4-difluorophenyl)propan-2-ol 
• 288-88-0 1,2,4-Triazole 
• 219923-95-2 3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol 
• 141113-36-2 2-(2,4-difluorophenyl)allyl alcohol 
• 164347-62-0 1,2-epoxy-3-chloro-2-(2,4-difluorophenyl)-propane 
• 60-29-7 diethyl ether 
• 75-09-2 dichloromethane 
• 149882-16-6 (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 149809-36-9 Toluene-4-sulfonic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 159553-75-0 Acetic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 141113-42-0 (S)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 
• 173837-49-5 1,3-diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-73-5 (S)-2-(2,4-difluorophenyl)-1-isobutyryloxy-3-methanesulfonyloxy-2-propanol 
• 173837-64-4 (R)-2-(2,4-difluorophenyl)-3-isobutyryloxy-1,2-propanediol 

Downstream Products

• 170985-70-3 (S)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 170985-69-0 (R)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate 

Relevant articles and documents

Method for asymmetrically opening ring of 3-substituted oxetane and application

The invention discloses a method for catalytically asymmetrically opening a ring of 3-substituted oxetane by using halogen. The method comprises the following steps: with 3-substituted oxetane and a halogen nucleophile as reaction substrates, under the ac

Asymmetric synthesis, antifungal activity and molecular modeling of iodiconazole isomers

Iodiconazole is a novel antifungal agent that was developed in its racemic form. In order to investigate the effects of the chiral center on the antifungal activity, R- and S-isomers of iodiconazole were prepared on the basis of the asymmetric Sharpless epoxidation. (S)-Iodiconazole was proved to have better antifungal activity than the (R)-isomer. The binding modes of the two isomers with lanosterol 14α-demethylase were clarified by molecular docking. Two isomers of iodiconazole, a novel antifungal agent, were prepared by asymmetric synthesis. Their antifungal activity and binding modes were investigated. Copyright

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.