14114-05-7 Usage
Description
Cyclopropyltriphenylphosphonium bromide is a white to slightly yellowish crystalline powder that possesses unique chemical properties and exhibits cytotoxic activity against certain cancer cell lines. It is commonly utilized as a Wittig reagent in organic chemistry and has been studied for its potential antitumor activity.
Uses
Used in Pharmaceutical Industry:
Cyclopropyltriphenylphosphonium bromide is used as a cytotoxic agent for its potential antitumor activity against tissue culture cells originating from human epidermoid carcinoma of the nasopharynx (KB). It modulates cellular processes and exhibits inhibitory effects on tumor growth, making it a promising candidate for cancer research and treatment.
Used in Chemical Synthesis:
Cyclopropyltriphenylphosphonium bromide is used as a versatile Wittig reagent in the synthesis of various organic compounds. It plays a crucial role in the preparation of keto halides, which are then subjected to sequential azidation and intramolecular Schmidt reactions. This reagent is also employed in the synthesis of cycloporpylidenemethylarylethynynes and dipeptides containing azabicyclo[3.1.0]hexane, showcasing its importance in the development of complex molecular structures.
Used in Electrolytic Polarization of Zinc (Zn):
In the metallurgical industry, cyclopropyltriphenylphosphonium bromide is used for the electrolytic polarization of zinc. This application aids in enhancing the efficiency of zinc extraction processes and contributes to the overall improvement of metal production techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 14114-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,1 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14114-05:
(7*1)+(6*4)+(5*1)+(4*1)+(3*4)+(2*0)+(1*5)=57
57 % 10 = 7
So 14114-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H20P/c1-4-10-18(11-5-1)22(21-16-17-21,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,21H,16-17H2/q+1
14114-05-7Relevant articles and documents
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Utimoto,K. et al.
, p. 1169 - 1171 (1973)
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Schweizer et al.
, p. 336 (1968)
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Process for the Preparation of (3E, 7E)-Homofarnesol
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Paragraph 0095-0097, (2013/10/22)
The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations with an increased content of (3E,7E)-homofarnesol (also referred to as all E-homofarnesol).
Polylithiumorganic compounds -19. Regioselective carbon-carbon σ-bond scission followed by a 1,6-proton shift upon the reductive metalation of benzylidenecyclopropane derivatives with lithium metal
Maercker, Adalbert,Daub, Volker E. E.
, p. 2439 - 2458 (2007/10/02)
Depending on the substituent α-substituted benzylidenecyclopropanes (32) react more or less readily with lithium dust (2% sodium) in diethyl ether whereby a regioselective scission of only the cyclopropane σ-bond cis to the phenyl ring takes place. Upon raising the temperature the primarily formed 1,3-dilithiumorganic compound due to an agostic interaction rearranges by a 1,6-proton shift into a doubly bridged 1,4-dilithio compound. With α-methylbenzylidenecyclopropane (32c) this rearrangement was shown to occur intermolecularly via a trilithiumorganic compound 56. The suggested mechanism of these reductive metalation reactions via a bisected radical anion 87 where the lithium is mainly bound to the cyclopropyl carbon atom and oriented syn to the phenyl ring, was supported by MNDO (geometries) and ab initio (energies) calculations.
