1412423-25-6Relevant articles and documents
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
Manzoni, Leonardo,Belvisi, Laura,Potenza, Donatella,Vasile, Francesca,Seneci, Pierfausto,Bianchi, Aldo,Drago, Carmelo,De Matteo, Marilenia,Ferrante, Luca,Scolastico, Carlo,Timpano, Gabriele,Rizzo, Vincenzo,Conti, Annalisa,Perego, Paola,Mastrangelo, Eloise,Servida, Federica
, p. 6687 - 6708,22 (2012/12/12)
Novel pro-apoptotic, homo- and heterodimeric Smac mimetics/IAPs inhibitors based on the N-AVPI-like 4-substituted 1-aza-2-oxobicyclo[5.3.0]decane scaffold were prepared from monomeric structures connected through a head-head (8), tail-tail (9) or head-tail (10) linker. The selection of appropriate decorating functions for the scaffolds, and of rigid and flexible linkers connecting them, is described. The synthesis, purification and analytical characterization of each prepared dimer 8-10 is thoroughly described.
