1412457-40-9Relevant articles and documents
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
Yang, Yanhui,Voak, Andrew,Wilkinson, Shane R.,Hu, Longqin
supporting information, p. 6583 - 6586 (2013/01/14)
A series of potential DFMO prodrugs was designed through the incorporation of 4-nitrobenzyl ester or carbamate groups for potential activation by trypanosomal nitroreductase. It was found that only modification of N-amino group of DFMO by 4-nitro-2-fluorobenzyloxycarbonyl resulted in significant trypanocidal activity and could serve as a lead for further investigation.