141353-76-6 Usage
Description
Carvedilol acetate, also known as (±)-N-[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]-N-[2-(2-methoxyphenoxy)ethyl]acetamide, is an impurity of Carvedilol (C184625). Carvedilol is a nonselective β-adrenergic blocker with α1-blocking activity, which is used in the treatment of various cardiovascular conditions.
Uses
Used in Pharmaceutical Industry:
Carvedilol acetate is used as an active pharmaceutical ingredient for the development of antihypertensive medications. It is particularly effective in the treatment of congestive heart failure due to its dual action as a β-adrenergic blocker and α1-blocker, which helps in managing high blood pressure and improving heart function.
Additionally, carvedilol acetate may be used in the development of other cardiovascular drugs, given its potential benefits in managing conditions such as angina, arrhythmias, and myocardial infarction. Its application in these areas is still under investigation and may vary depending on the specific formulation and dosage used.
Check Digit Verification of cas no
The CAS Registry Mumber 141353-76-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,3,5 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 141353-76:
(8*1)+(7*4)+(6*1)+(5*3)+(4*5)+(3*3)+(2*7)+(1*6)=106
106 % 10 = 6
So 141353-76-6 is a valid CAS Registry Number.
141353-76-6Relevant articles and documents
Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Bergdahl, Ingvar A.,Conway, Louis P.,Correia, Mário S. P.,Globisch, Daniel,Rendo, Veronica,Sj?blom, Tobias
supporting information, p. 14342 - 14346 (2020/07/13)
N-Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N-acetyltransferase NAT2 also acetylates aliphatic endogenous amines. Metabolomic analysis and chemical synthesis revealed increased intracellular concentrations of mono- and diacetylated spermidine in human cell lines expressing the rapid compared to the slow acetylator NAT2 phenotype. The regioselective N8-acetylation of monoacetylated spermidine by NAT2 answers the long-standing question of the source of diacetylspermidine. We also identified selective acetylation of structurally diverse alkylamine-containing drugs by NAT2, which may contribute to variations in patient responses. The results demonstrate a previously unknown functionality and potential regulatory role for NAT2, and we suggest that this enzyme should be considered for re-classification.
