1413923-31-5

Basic information

• Product Name: C₁₈H₁₄N₂O₂
• Synonyms: C₁₈H₁₄N₂O₂
• CAS NO: 1413923-31-5
• Molecular Weight: 290.321
• Mol File: 1413923-31-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₄N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₄N₂O₂(1413923-31-5)
• EPA Substance Registry System: C₁₈H₁₄N₂O₂(1413923-31-5)

Safety Data

• Hazardous Substances Data: 1413923-31-5(Hazardous Substances Data)

Upstream product

• 3717-21-3 p-methoxyl benzaldoxime 
• 889108-48-9 5-ethynyl-1H-indole 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 10075-50-0 5-bromo-1H-indole 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Synthesis of 3,5-Disubstituted isoxazoles containing privileged substructures with a diverse display of polar surface area

We designed and synthesized the molecular framework of 3,5-disubstituted isoxazoles containing privileged substructures with various substituents which uniquely display polar surface area in a diverse manner. A library of 3,5-disubstituted isoxazoles were systematically prepared via 1,3-dipolar cycloaddition of alkynes with nitrile oxides prepared by two complementary synthetic routes; method A utilized a halogenating agent with a base and method B utilized a hypervalent iodine reagent. Through the biological evaluation of corresponding isoxazoles via three independent phenotypic assays, the different pattern of biological activities was shown according to the type of privileged substructure and substituent. These results demonstrated the significance of molecular design via introducing privileged substructures and various substituents to make a diverse arrangement of polar surface area within a similar 3-dimensional molecular framework.